This patented hydrogel is made with
Amelogenin is a substance which is used for the
building of tooth enamel in both humans and animals. Peptide is a chain from
Moradian-Oldak received 3 grants to keep up with her
work. With one grant, she will be able to test the usage of amelogenin-derived
peptides in the gel.
She notes that the short peptides, like the one she
uses, have several advantages over the longer ones. That is, they’re less expensive
and the process of getting FDA approval is easier. The peptides could be put
into a gel and applied onto eroded teeth.
She’s also discovered that the peptide is able to
regrow the aprismatic-like layer of the teeth. The research team will now need
to test if this hydrogel will work well for the dentin remineralization.
With the second grant, they’ll be focused on
understanding the structural biology of the tooth enamel whereas the third one
is an exploratory proposal. The idea is to use chemistry methods to produce a
material which will be similar to the properties of enamel.
In order to test the hydrogels, the scientific team
used a diamond saw and sliced wisdom teeth into uniform thin discs and then
painted them with a nail polish, a clear one.
Then, they left a small part unpainted. Afterwards,
they put the slices in acid to demineralize the exposed parts and stimulate the
formation of lesions or artificial cavities.
To see how the gel helps in the promotion of new enamel growth, they placed it onto the lesions and put the tooth in artificial saliva made from calcium phosphate.
Oldak explains that they don’t plan on jeopardizing dentistry jobs because even though if this patent becomes an available treatment, we would still need to go to regular dentist checkups.
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